Molecular tumor characterization

Our team leverages cutting-edge technologies to perform high-resolution molecular analysis of biological samples from both veterinary and human patients.
Key Technologies include
 

• Tissue-defined multi-omics analysis: We utilize laser-capture microdissection followed by RNA sequencing and LC-MS/MS (liquid chromatography-mass spectrometry/mass spectrometry) to analyze specific, targeted areas within archival FFPE (formalin-fixed paraffin-embedded) samples. This provides an unbiased way to compare molecular similarities and differences across species.
• Functional Assessment Platforms: Our process integrates functional assessment tools for analyzing patient-derived cells and cell lines, which aids in identifying novel pharmacological strategies.
• Single-cell RNA Sequencing: We apply modern single-cell RNA sequencing techniques directly to fresh patient tissue to assess the impact of inter- and intratumor heterogeneity and immune infiltration on patient outcome in response to therapy.
• Single-cell spatial RNA Sequencing: The latest integration involves moving towards tissue analysis with single-cell resolution using Xenium-based spatial single-cell RNA sequencing, applied in a unique cross-species research setup.